I've got that same drive, Al, and haven't run into a problem with it once I installed the latest firmware update.
Creating a bootable OS-only clone should work fine using the Safety Clone script. You'll need somewhere around 8-12GB. To figure out how much, try creating one on a temporary volume. Add a few GB for temporary files and swap files, and there you go.
(As an iTunes library tip -- you can burn a playlist pretty easily to DVDs, so examine the built-in backup capabilities it's got...)
Hope that helps!
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--Dave Nanian
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